Biocompatibility and Tissue Regeneration Ability of the artificial dura mater DuraBeam was presented at CNTT2025/JSAN2025, Osaka International Convention Center. Please see the abstract below.
The 34th Coference on Neurosurgical Techniques and Tools (CNTT2025)
The 18th Annual Meeting if the Japan Society of Aesthetic Neurosurgery (JSAN2025)
Saturday, April 19th, 2025 Osaka International Convention Center Hall 4
9:35-9:50 JSAN2025 Opening Ceremony, Chair: Haruhiko Kijima, Department of Neurosurgery, Graduate School of Medicine, Osaka University
9:50-10:50 CNTT/JSAN Joint Oral Presentation “Revolution in Surgical Materials” Chair: Hiroyoshi Akutsu, Department of Neurosurgery, Dokkyo Medical University Tetsuyoshi Horiuchi, Department of Neurosurgery, Shinshu University School of Medicine
CJO-2
Exploratory study on the biocompatibility and tissue regeneration ability of artificial dura mater DuraBeam
Tomohito Nagai(1), Daisuke Ando(1), Keita Tominaga(2), Jun Nakayashiki(3), Shinichiro Osawa(1), Hidenori Endo(1), Kuniyasu Niizuma(4)
(1) Department of Neurosurgery, Graduate School of Medicine, Tohoku University, (2) Department of Neurosurgery, Konan Hospital, (3) Department of Neurosurgery, Iwate Prefectural Central Hospital, (4) Department of Advanced Treatment Development, Neurosurgery, Graduate School of Medicine, Tohoku University
[Objective]
Expanded polytetrafluoroethylene (ePTFE), the material used for artificial dura mater, has poor biocompatibility and poor adhesion to the patient’s own dura mater, which can lead to problems such as postoperative cerebrospinal fluid leakage. The feature of DuraBeam is that it improves biocompatibility by increasing cell adhesion through ion beam irradiation of ePTFE. We have observed cases in which the artificial dura became transparent and new tissue grew after dura plasty using DuraBeam, and therefore conducted an exploratory study on the mechanism of biocompatibility of this product.
[Method and Results]
An artificial dura was placed in the rat skull to confirm its reactivity with the living body. 4.5 months after placement, the artificial membrane became semitransparent, and a pale yellow biological membrane had formed around it. In addition, when DuraBeam was placed in the abdominal cavity of a mouse, the artificial dura became semitransparent and a biological membrane grew with angiogenesis. Histologically, numerous multinucleated giant cells with phagocytosis of ePTFE were observed on the surface of the ion-irradiated side, and infiltration of cellular components was observed within the artificial membrane. Electron microscopy images showed fibroblast- and macrophage-like tissue on the surface of the artificial membrane. When the excised tissue was cultured, proliferation of fibroblasts and mesenchymal stem cell-like cells was observed, and immunohistological examination showed a mixture of multiple cell types, including stem cells. When these cells were analyzed by single-cell RNA sequencing, they could be divided into 12 cell populations based on gene expression levels, and it was estimated that multiple cell types were present, including fibroblasts, mesenchymal stem cells, and macrophages.
[Conclusion]
Long-term placement of the artificial dura mater DuraBeam resulted in the transparency of the DuraBeam and the formation of a new biological membrane, and it was revealed that the cell population that makes up the biological membrane included mesenchymal stem cells. These results suggest that DuraBeam has biocompatibility and may serve as a scaffold for tissue repair.
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